TARGET THE ACHILLES HEEL
OF CANCER METASTASIS

INTO A WORLD
WITHOUT METASTASIS

FIRST-IN-CLASS
INVADOPODIA-TARGETED
GENE THERAPY

DRAMATIC TUMOR SHRINKAGE
WITHOUT CHEMOTHERAPY

OVERVIEW

Metastasis and recurrence are the primary causes of cancer mortality. Despite recent advances in molecularly targeted and immuno-oncology therapy, treating or preventing cancer recurrence and/or metastasis remains a hugely unmet clinical need. Most anti-cancer therapies are designed to shrink primary tumors but cannot prevent metastases. Invadopodia (a.k.a. “cellular feet”) are the driving force of invasion, growth, and metastasis of cancer cells in the three-dimensional microenvironments in vivo. Antapodia Therapeutics pioneers the identification of a series of "Master Invadopodial Regulator (MIRs)", which are exclusively expressed by invasive cancer cells and thereby can serve as ideal and safe therapeutic targets. The company develops first-in-class and powerful siRNA therapy and monoclonal antibodies (mAb) to target MIRs, which provides an excitingly new avenue to treating aggressive and metastatic cancers.

NANO GENE-THERAPY

Many human solid tumors, such as liver, breast, lung, and pancreatic cancers, are characterized by a highly dense fibrotic stroma termed “desmoplasia”, which impedes the penetration of therapeutics. Nanoparticle formulation is a clinically proven strategy to facilitate drug penetration in desmoplastic cancers, such as liposomal doxorubicin in breast cancer and liposomal irinotecan in pancreatic cancer. Lipid nanoparticle (LNP)-formulated small interfering RNA (siRNA) and gene-editors have recently emerged as clinically proven strategies of the precision targeting of disease driver genes. Antapodia Therapeutics combines next-generation LNPs and a novel "liver-blocking" technology to deliver invadopodia-targeted siRNA and gene editors to hepatic, non-hepatic and/or metastatic cancers, providing an exciting new aveue for treating aggressive human cancers.

PIPELINE

Product

AP-01 LNP-siRNA

(HCC, TNBC, SCLC)

Target Gene

MIR-01

 

PoM/PoC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

Product

AP-02 LNP-siRNA

(GAC, liver metastasis)

Target Gene

MIR-02

 

PoM/PoC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

Product

AP-03 mAb

(CRPC, GAC)

Target Gene

MIR-03

 

PoOM/PoC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

Product

AP-04 LNP-base editor

 

Target Gene

MIR-01

 

PoM/PoC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

MIR: Master Invadopodial Regulator; LNP: lipid nanoparticle; siRNA: small interfering RNA; MIR: Master Invadopodial Regulator; HCC: hepatocellular carcinoma; TNBC: triple-negative breast cancer; SCLC: small cell lung cancer; GAC: gastric adenocarcinoma; CRPC: castration-resistant prostate cancer; mAb: monoclonal antibody.

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Designed by Justin V. Tsai in 2021

Copyright © Antapodia Therapeutics, Inc., WA, USA. All Rights Reserved.

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