TARGET THE ACHILLES HILL
OF CANCER METASTASIS

INTO A WORLD
WITHOUT METASTASIS

FIRST-IN-CLASS
INVADOPODIA-TARGETED
GENE THERAPY

DRAMATIC TUMOR SHRINKAGE
WITHOUT CHEMOTHERAPY

OVERVIEW

Metastasis and recurrence are the major causes of cancer mortality. Despite recent advances in molecularly targeted and immuno-oncology therapy, treating or preventing cancer recurrence and/or metastasis remains a hugely unmet clinical need. Most existing anti-cancer therapeutics only shrink primary tumors without affecting metastatic ones. Invadopodia (a.k.a. “cellular feet”) are the driving force of invasion, growth, and metastasis of cancer cells in the three-dimensional microenvironments in vivo. Antapodia Therapeutics pioneers the identification of a series of "Master Invadopodial Regulator (MIRs)", which are exclusively expressed by invasive cancer cells and thereby can serve as ideal and safe therapeutic targets. The company develops first-in-class and powerful siRNA therapy and monoclonal antibodies (mAb) to target MIRs, which provides an excitingly new avenue to treating aggressive and metastatic cancers.

LNP-siRNA GENE THERAPY

Many solid tumors, such as liver, breast, and pancreatic cancers, are characterized by a highly dense fibrotic stroma termed “desmoplasia”, which impedes the penetration of most therapeutics. Nanoparticle formulation is a clinically proven strategy to facilitate drug penetration in desmoplastic cancers, such as liposomal doxorubicin in breast cancer and liposomal irinotecan in pancreatic cancer. Lipid nanoparticle (LNP)-formulated small interfering RNA (siRNA) therapeutics have recently emerged as a safe and efficient approach in the molecular targeting of disease driver genes such as transthyretin in liver amyloidosis and ALAS1 in acute hepatic porphyria. Antapodia Therapeutics combines the third-generation LNP and a proprietary liver-blocking technology to deliver invadopodia-targeted siRNA to both hepatic and non-hepatic cancers, which show tremendous anti-tumor and anti-metastasis efficacy in various tumor models.

PIPELINE

Product (Target Diseases)

AP-01 (LNP-siRNA)

(HCC, TNBC, SCLC)

Target & Companion Dx

MIR-01

               

POM/POC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

Product (Target Diseases)

AP-02 (LNP-siRNA)

(GAC)

Target & Companion Dx

MIR-02 & ligand

 

POM/POC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

Product (Target Diseases)

AP-03 (mAb)

(CRPC, GAC)

Target

MIR-03

 

POM/POC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

MIR: Master Invadopodial Regulator; LNP: lipid nanoparticle; siRNA: small interfering RNA; MIR: Master Invadopodial Regulator; HCC: hepatocellular carcinoma; TNBC: triple-negative breast cancer; SCLC: small cell lung cancer; GAC: gastric adenocarcinoma; CRPC: castration-resistant prostate cancer; mAb: monoclonal antibody.

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Designed by Justin V. Tsai in 2021

Copyright © Antapodia Therapeutics, Inc., WA, USA. All Rights Reserved.

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