INVADOPODIA

Invadopodia (a.k.a. “cellular feet”) are transient actin-based protrusions on invading cancer cells that generate forces to displace extracellular matrices (ECM) and induce their focal degradation by the localized proteolytic activity of proteases. Cancer cells use invadopodia to displace, degrade and invade ECM structures. Invadopodia are considered as the transformed version of podosomes that are formed on normal motile cells such as macrophages, lymphocytes, dendritic cells, osteoclasts, endothelial cells and smooth muscle cells. Importantly, invadopodia are found to exist in vivo and contribute to the invasion of cancer cells into the surrounding stroma, their intravasation into the vasculature as well as extravasation toward distant metastatic sites.

 

The process through which cancer cells use their invadopodia to invade the surrounding tissues is amazingly similar to an octopus using its legs to explore their surrounding and squeeze through a small hole. The same “escape” mechanism is utilized in biology at both the single cell and the whole organism levels.

References

  1. Ridley AJ. Life at the leading edge. Cell 2011;145, 1012-1022.

  2. Murphy DA, Courneidge SA. The ‘ins’ and ‘outs’ of podosomes and invadopodia: characteristic, formation and function. Nat Rev Mo. Cell Biol 2011;12, 413-426.

  3. Paz H, Pathak N, Yang J. Invading one step at a time: the role of invadopodia in tumor metastasis. Oncogene 2014;33, 4193-4202

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