TARGETS

 

Master Invadopodia Regulator 2 (MIR-2)

MIR-2 is a transmembrane receptor that is predominantly localized to the invadopodia on invasive cancer cells in different types of human cancers (Figure 1). MIR-2-expressing cancer cells are proficient in invadopodia formation and are highly invasive and pro-metastatic (Figure 2). Consistently, the expression of MIR-1 negatively correlates with the survival of patients in multiple types of metastatic cancers (Figure 3). Activation of cell-surface MIR-2 leads to the activation of protein kinase C, small GTPases, and epithelial-mesenchymal-transition pathways to promote the invadopodial functions and cell invasiveness. As such, genetic knockdown of MIR-2 blocks the formation of invadopodia in invasive cancer cells (Figure 4), thereby inhibiting cancer invasiveness (Figure 5).

Figure 1. MIR-2 is specifically localized to the invadopodia on invasive pancreatic cancer cells

Figure 1. MIR-2 is specifically localized to the invadopodia in invasive cancer cells

Figure 2. Pancreatic cancer cells expressing MIR-2 are proficient in generating invadopodia (A) and are highly invasive (B) and pro-metastatic (C)

Figure 3. Genetic knockdown of MIR-2 abrogates invadopodia formation in invasive cancer cells

Figure 3. MIR-2 expression correlates with shorter overall survival of cancer patients.

Figure 2. MIR-2 expression correlates with shorter overall survival of cancer patients.
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