TARGETS

 

Master Invadopodial Regulator 3 (MIR-03)

MIR-03 is a secreted protein selectively attached to the invadopodial surface on invasive cancer cells (Figure 1). MIR-03-expressing cancer cells are proficient in invadopodia formation and are highly invasive and pro-metastatic (Figure 2). The expression of MIR-03 negatively correlates with the survival of patients in multiple types of metastatic cancers (Figure 3). MIR-03 activates matrix metalloproteinases (MMPs) around the invadopodia to promote their extension, leading to cancer cell invasion and metastasis. Functional blockage of MIR-03 using its neutralizing antibody inhibits the invadopodial formation and thereby cancer cell invasiveness (Figure 4).

Figure 1. MIR-03 is specifically attached to the invadopodial surface on invasive cancer cells

Figure 1. MIR-1 is specifically localized to the invadopodia in invasive cancer cells

Shown is a representative three-dimensional reconstituted confocal image of the undersurface of an invasive cancer cell. MIR-03 is seen on the feet-like invadopodia (red spikes) penetrating into the underlying matrix. The cell body is stained with a-tubulin (green) with the nuclei counterstained with Hoechst 33342 (blue).

Figure 2. MIR-03-expressing cancer cells are proficient in generating invadopodia (A) and are highly invasive (B) and pro-metastatic (C)

Figure 1. MIR-1 is specifically localized to the invadopodia in invasive cancer cells

Figure 3. MIR-03 expression correlates with shorter survival of cancer patients

Figure 3. MIR-03 expression correlates with shorter survival of cancer patients

Shown are the overall survival of patients in the target cancer types stratified based on the expression levels of MIR-03. The data were interrogated from The Cancer Genome Atlas (TCGA), SurvExpress, and KM Plotter.

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